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From Sikeston:
Take Interstate 55 south to Interstate 57. Merge onto the I-57 N./U.S. 60 E.
Exit (Exit 66A toward Chicago) and go north on I-57. Take the Charleston/
East Prairie Exit (Exit 10). (From Sikeston: about 12 miles)
From Cairo, IL:
Take Interstate 57 south for about 13 miles to the Charleston/East Prairie Exit (Exit 10).